The pelletizing process for the production of pharmaceutical pellets - including extrusion and spheronization, production of pellets by powder layering and liquid layering and pelletization via fluid bed coating and fluid bed granulation processes.
Machine + : One machine for granulation, blending and extrusion and spheronization. (batch sizes from 100 gms to 20 Kgs./ batch or more high throughput available on request)
The centre of the Umang Pharmaceutical Systems services has developed small scale and R&D approach is Machine+. This innovative system provides a unique benefit to the Pharmaceutical Development industry, integrating a single Control Unit with a wide range of Process Modules like high shear mixing from 100 gms./batch capacity to 20 kgs./ batch, pelletizing, extrusion and spheronization.
Pharmaceutical Pellets offer many additional features compared to conventional tablets. Umang Pharmaceutical Systems is able to offer all the typically used pelletization processes like mixing cum extrusion, screw extrusion, radial extrusion, pressure extrusion, basket extrusion, radial extrusion, cone extrusion, dome extrusion, die roller extrusion, etc. and assist with the selection of the process that best suits your needs and products, we at Umang pharmaceutical services have around 100 pellet products that we manufacture for sale to our customers, we not only give the machines, but the pellet technology and products with technology transfer too.
The UMANG Pelletizing System is a turnkey pellet production plant, which combines mixer/granulator, extruder and spheronizer in a single, integrated process. Continuously wet powders pass through a low-shear radial extruder / cone extruder / pressure extruder / basket extruder. The extrusions are fragmented and formed into pellets in the spheronizer.
We have single and twin spheroidization options possible in the integrated system, for high throughput systems we recommend single extruder and twin spheronizers with twin bucket assembly for feeding the spheronizers.
The multi-functional fluid bed rotor and fluid bed coater systems can all be used to make pellets by layering the active material onto an inert core. Non-pareil starter pellets are sprayed with a solution or suspension of the active material, and dried simultaneously.
When the active ingredient is in powder form, pelletization can be achieved by spraying starter pellets with the active powder and at the same time a liquid binder solution, UMANGs technology has automated sensors to control the liquid spray and powder spray on the starter core, this eliminates manual handling of the process and makes it robust and . The layered pellets are then dried and taken for further coating processes like sustained release, enteric coating, etc.
Melt extrusion is performed in the HOT MELT EXTRUSION. The active and binder powders are mixed and heated to a temperature above the melting point of the binder. Granulation and pelletization are then carried out in a single operation machine which is twin screw hot melt, UMANG has a dozen of systems in operation for hot melt granulation, cooling and cutting of the granules into desired form and shape.
The active substance is mixed with 5-30% microcrystalline cellulose and the mixture granulated with water or an organic solvent. During the process the granules are compacted and spheronized. This operation can be performed using the FLUID BED ROTOR